An Unexpected Link between Lipooligosaccharide Biosynthesis and Pe_pgrs Protein Secretion in Mycobacterium Marinum
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چکیده
Background: Various cell surface proteins of pathogenic mycobacteria have been implicated in virulence. Results: A screen for secretion defects of specific cell surface proteins in Mycobacterium marinum identified predominantly lipooligosaccharide (LOS) biosynthesis mutants. Conclusion: Defects in LOS biosynthesis alter the release of cell surface proteins. Significance: Ten novel genes are described for LOS biosynthesis and increased virulence is observed for a LOS-IV mutant.
منابع مشابه
Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum.
The mycobacterial cell envelope is characterized by the presence of a highly impermeable second membrane, which is composed of mycolic acids intercalated with different unusual free lipids, such as lipooligosaccharides (LOS). Transport across this cell envelope requires a dedicated secretion system for extracellular proteins, such as PE_PGRS proteins, which are specific mycobacterial proteins w...
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تاریخ انتشار 2012